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Prostate-specific membrane antigen (PSMA) PET/CT has become an unparalleled modality in the diagnosis of primary and recurrent prostatic adenocarcinoma, often revealing sites of disease that were previously invisible on conventional imaging. In this 78-year-old man with suspected prostate cancer recurrence, PSMA PET/CT revealed focal radiotracer uptake in the brain, which would ordinarily raise suspicion for metastases, but was a false positive in the setting of a recent stroke. Increased PSMA uptake has been reported in subacute infarcts and primary and secondary brain tumors. Careful history and comparison with prior imaging are vital to avoid false-positive diagnosis in such patients.
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Jain et al. (Mon,) studied this question.
www.synapsesocial.com/papers/68e61188b6db6435875a41c2 — DOI: https://doi.org/10.1097/rlu.0000000000005373
Vaibhav Jain
Lacey McIntosh
Clinical Nuclear Medicine
University of Massachusetts Chan Medical School
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