Solvent- and catalyst-free green protocol for para-hydroxybenzylation of NH-azoles

Key Points

• The aim is to develop a solvent- and catalyst-free method for para-hydroxybenzylation of various NH-azoles.
• Developed a non-catalytic approach for the reaction.
• Utilized p-hydroxybenzyl alcohols as reagents.
• Conducted reactions in the absence of solvent.
• Focused on imidazoles, benzimidazoles, and triazoles.
• Achieved high product yields from the reactions.
• Noted short reaction times for the synthesis.
• Highlighted simplicity in isolation and purification processes.
• Demonstrated high atom economy throughout the synthesis.