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A non-catalytic method demonstrates high yields in para-hydroxybenzylation of NH-azoles, suggesting an efficient synthesis approach.
A non-catalytic method for the para -hydroxybenzylation of NH-azoles that differ significantly in nucleophilicity and basicity (imidazoles, benzimidazoles, 1,2,4-triazoles and others) with p -hydroxybenzyl alcohols in the absence of solvent has been developed. The synthesis uses available reagents and is characterized by high product yields, short reaction times, simplicity of isolation and purification, and high atom economy.
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Vitaly A. Osyanin (2026) studied this question.
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