Epigenetic analyses suggest different pathways during pregnancy for development of Type 1 diabetes in children with high versus low-neutral human leukocyte antigen-risk. | Synapse
February 27, 2026
Epigenetic analyses suggest different pathways during pregnancy for development of Type 1 diabetes in children with high versus low-neutral human leukocyte antigen-risk.
Key Points
This research aims to investigate how different human leukocyte antigen (HLA) backgrounds influence the pathways involved in the development of type 1 diabetes (T1D) during pregnancy.
Conducted epigenetic analyses to assess T1D risk
Classified subjects based on high and low HLA risk
Analyzed disease pathways during pregnancy
Identified distinct pathogenetic mechanisms for T1D based on HLA background
Demonstrated that HLA risk level may influence disease development pathways
Abstract
These findings indicate that heterogeneity in T1D pathogenetic mechanisms based on HLA background may influence disease development.