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February 25, 2026

Epigenetic analyses suggest different pathways during pregnancy for development of Type 1 diabetes in children with high versus low-neutral human leukocyte antigen-risk.

Shamila Darvish Alipoor Angelica P. Ahrens Julia Åkesson Thomas Hillerton Mika Gustafsson Maria Lerm Johnny Ludvigsson

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Key Points

This research aims to investigate how different human leukocyte antigen (HLA) backgrounds influence the pathways involved in the development of type 1 diabetes (T1D) during pregnancy.
Conducted epigenetic analyses to assess T1D risk
Classified subjects based on high and low HLA risk
Analyzed disease pathways during pregnancy
Identified distinct pathogenetic mechanisms for T1D based on HLA background
Demonstrated that HLA risk level may influence disease development pathways

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Implication

Epigenetic analyses reveal differing pathways for type 1 diabetes development in children based on HLA risk.

Abstract

These findings indicate that heterogeneity in T1D pathogenetic mechanisms based on HLA background may influence disease development.

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Cite This Study

Alipoor et al. (2026) studied this question.

synapsesocial.com/papers/69a1351ded1d949a99abeaa5 https://doi.org/10.1111/joim.70077

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