Proton pump inhibitors modulate esophageal epithelial barrier function and crosstalk with eosinophils.

Key Points

• The study aims to investigate how proton pump inhibitors affect esophageal epithelial barrier function and eosinophil interactions.
• Utilized an epithelial air-liquid interface model
• Conducted eosinophil-epithelial co-culture experiments
• Assessed changes in barrier function and chemokine expression
• Omeprazole reduced the negative impact of IL-13 on epithelial cells
• Improved barrier dysfunction and reduced chemokine expression
• Decreased eosinophil adhesion marker levels