Proton pump inhibitors modulate esophageal epithelial barrier function and crosstalk with eosinophils.

Ravi Gautam; Megha Lal; Margaret C. Carroll; Zoe Mrozek; Tina Trachsel; Jarad Beers; Amanda B. Muir

doi:10.1111/pai.70315

March 1, 2026

Proton pump inhibitors modulate esophageal epithelial barrier function and crosstalk with eosinophils.

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Key Points

The study aims to investigate how proton pump inhibitors affect esophageal epithelial barrier function and eosinophil interactions.
Utilized an epithelial air-liquid interface model
Conducted eosinophil-epithelial co-culture experiments
Assessed changes in barrier function and chemokine expression
Omeprazole reduced the negative impact of IL-13 on epithelial cells
Improved barrier dysfunction and reduced chemokine expression
Decreased eosinophil adhesion marker levels

Implication

Research shows proton pump inhibitors improve barrier function and reduce eosinophil activity in eosinophilic conditions, suggesting potential therapeutic benefits.

Abstract

Omeprazole diminished the effects of IL-13 in both the epithelial air-liquid interface model and eosinophil-epithelial co-cultures, alleviating barrier dysfunction, chemokine expression, and the upregulation of eosinophil adhesion markers.

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Cite This Study

Gautam et al. (2026) studied this question.

synapsesocial.com/papers/69a52e56f1e85e5c73bf1f45 https://doi.org/10.1111/pai.70315

View Full Paper

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Proton pump inhibitors modulate esophageal epithelial barrier function and crosstalk with eosinophils.

Key Points

Implication

Abstract

Discussion

Cite This Study

Proton pump inhibitors modulate esophageal epithelial barrier function and crosstalk with eosinophils.

Key Points

Implication

Abstract

Discussion

Cite This Study

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