Relevance analysis of N-glycan variations in C2C12 cells and mouse serum under simulated microgravity using a quaternary phosphonium hydrazide labeling strategy-based mass spectrometry quantitation approach | Synapse
March 3, 2026
Relevance analysis of N-glycan variations in C2C12 cells and mouse serum under simulated microgravity using a quaternary phosphonium hydrazide labeling strategy-based mass spectrometry quantitation approach
Key Points
Significant n-glycan variations detected in C2C12 cells under microgravity conditions, indicating altered cellular behavior.
Using a mass spectrometry quantitation approach, distinct changes in glycan profiles were measured.
The study highlights a novel labeling strategy with quaternary phosphonium hydrazide to enhance detection.
Results suggest that analyzing n-glycans may provide insights into cellular mechanisms affected by microgravity.