L-shaped association between fasting blood glucose and comorbid anxiety in Chinese patients with first-episode untreated major depressive disorder

Key Points

• An elevated risk of comorbid anxiety is linked to lower fasting blood glucose levels.
• Specifically, when fasting blood glucose falls below 4.8 mmol/L, the anxiety risk increases significantly.
• Analysis based on first-episode untreated major depressive disorder in Chinese Han individuals reveals notable patterns.
• These findings highlight a need for attention to glucose levels in managing anxiety within depressive disorders.