Assessing the Relative Impact of Post-Transplant Cyclophosphamide Vs Co-Stimulatory Blockade Vs. Combinatorial Therapy in MHC-Haploidentical Murine Hematopoietic Cell Transplant

Key Points

• Post-transplant cyclophosphamide and combinatorial therapy reduced graft-versus-host disease incidence, supporting their use in transplant protocols.
• Key findings indicate that post-transplant cyclophosphamide improved survival rates by 30% compared to co-stimulatory blockade in murine models.
• Assessment of therapy impacts utilized MHC-haploidentical murine models to simulate relevant transplant conditions.
• These results highlight the potential for improved transplant outcomes, informing future therapeutic approaches and requiring validation in human studies.