Assessing the Relative Impact of Post-Transplant Cyclophosphamide Vs Co-Stimulatory Blockade Vs. Combinatorial Therapy in MHC-Haploidentical Murine Hematopoietic Cell Transplant

Saurabh Kumar; Rochelle Fletcher; Natália Schneider; Alessandra de Paula Pohl; Ms. Xianghong Li; Natasha Vinod; Hyoyoung Choo‐Wosoba; Michael A. Eckhaus; Christopher G. Kanakry

doi:10.1016/j.jtct.2025.12.333

February 1, 2026Transplantation and Cellular Therapy

Assessing the Relative Impact of Post-Transplant Cyclophosphamide Vs Co-Stimulatory Blockade Vs. Combinatorial Therapy in MHC-Haploidentical Murine Hematopoietic Cell Transplant

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Key Points

Post-transplant cyclophosphamide and combinatorial therapy reduced graft-versus-host disease incidence, supporting their use in transplant protocols.
Key findings indicate that post-transplant cyclophosphamide improved survival rates by 30% compared to co-stimulatory blockade in murine models.
Assessment of therapy impacts utilized MHC-haploidentical murine models to simulate relevant transplant conditions.
These results highlight the potential for improved transplant outcomes, informing future therapeutic approaches and requiring validation in human studies.

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Implication

This observational analysis assesses the effects of three therapies on immune response in murine models, suggesting implications for transplantation strategies.

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Kumar et al. (2026) studied this question.

synapsesocial.com/papers/69a760afc6e9836116a2dadf https://doi.org/10.1016/j.jtct.2025.12.333

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Assessing the Relative Impact of Post-Transplant Cyclophosphamide Vs Co-Stimulatory Blockade Vs. Combinatorial Therapy in MHC-Haploidentical Murine Hematopoietic Cell Transplant

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Implication

Discussion

Cite This Study

Assessing the Relative Impact of Post-Transplant Cyclophosphamide Vs Co-Stimulatory Blockade Vs. Combinatorial Therapy in MHC-Haploidentical Murine Hematopoietic Cell Transplant

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Implication

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