The dual G9a inhibitor and histamine H3 receptor antagonist A-366 improves repetitive and social behaviors and attenuates neuroinflammation in BTBR T + tf/J mice | Synapse
March 3, 2026Open Access
The dual G9a inhibitor and histamine H3 receptor antagonist A-366 improves repetitive and social behaviors and attenuates neuroinflammation in BTBR T + tf/J mice
Key Points
A-366 improves social and repetitive behaviors in BTBR T + tf/J mice, with notable behavioral enhancements observed.
The treatment led to a significant reduction in neuroinflammation, based on observed cytokine levels.
Assessment using a dual G9a inhibitor and histamine H3 receptor antagonist over a treatment period.
Results suggest A-366 may indicate new treatments for behavioral issues linked to neuroinflammation.