The dual G9a inhibitor and histamine H3 receptor antagonist A-366 improves repetitive and social behaviors and attenuates neuroinflammation in BTBR T + tf/J mice

Key Points

• A-366 improves social and repetitive behaviors in BTBR T + tf/J mice, with notable behavioral enhancements observed.
• The treatment led to a significant reduction in neuroinflammation, based on observed cytokine levels.
• Assessment using a dual G9a inhibitor and histamine H3 receptor antagonist over a treatment period.
• Results suggest A-366 may indicate new treatments for behavioral issues linked to neuroinflammation.