What question did this study set out to answer?

This research aims to evaluate the analgesic efficacy and adverse effects of the paracetamol-codeine combination following third molar surgery.

March 4, 2026Minerva Dental and Oral Science1 citations

Analgesic efficacy and adverse effects of paracetamol-codeine combination in third molar surgery: a meta-analytic systematic review

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ARA. RosaUniversity of Rome Tor Vergata MMM. MirandaUniversity of Rome Tor Vergata PBPaolo BarnabaUniversity of Rome Tor Vergata

Key Points

This research aims to evaluate the analgesic efficacy and adverse effects of the paracetamol-codeine combination following third molar surgery.
Conducted a meta-analysis of existing studies on paracetamol and codeine for postoperative pain relief.
Evaluated analgesic effectiveness in patients undergoing third molar surgery.
Analyzed the incidence of adverse effects associated with this combination.
Paracetamol-codeine provided effective pain relief for third molar surgery.
Increased risk of sedation and gastrointestinal symptoms observed in patients using this combination.

Abstract

Paracetamol + codeine provides effective postoperative analgesia for third molar surgery, especially in patients contraindicated for NSAIDs. Clinicians should consider the increased risk of sedation and gastrointestinal symptoms when prescribing this combination, and educate patients accordingly.

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Cite This Study

Rosa et al. (Sun,) studied this question.

synapsesocial.com/papers/69a7cd0bd48f933b5eed915b https://doi.org/https://doi.org/10.23736/s2724-6329.25.05216-7

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