Meta-analysis demonstrates analgesic efficacy of paracetamol-codeine in third molar surgery, highlighting risks of sedation and GI symptoms.
Paracetamol + codeine provides effective postoperative analgesia for third molar surgery, especially in patients contraindicated for NSAIDs. Clinicians should consider the increased risk of sedation and gastrointestinal symptoms when prescribing this combination, and educate patients accordingly.
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Rosa et al. (2026) studied this question.
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