Adverse events of oral analgesics after third molar extraction: A network meta-analysis of randomized controlled trials

The safety profile of single-dose analgesics in this model is complex. While pairwise comparisons and rankings suggested that NSAIDs might be associated with a higher frequency of adverse events, these findings are based on very low to low certainty evidence and likely reflect minor, transient events such as nausea. Additionally, the high incidence of events in the placebo group suggests that the nocebo effect plays a predominant role in event perception. Therefore, results regarding the comparative safety of NSAIDs should be interpreted with caution, balancing this potential risk against their superior analgesic efficacy.