Does targeted ablation of periostin-expressing activated fibroblasts prevent adverse cardiac remodeling in mice?
Targeted ablation of periostin-expressing activated fibroblasts is a promising preclinical approach to prevent adverse cardiac remodeling post-myocardial infarction and in response to angiotensin II.
Modulation of the activated CF population is a promising approach to prevent adverse cardiac remodeling in response to angiotensin II and after myocardial infarction.
Kaur et al. (Mon,) studied this question.