What does this research mean for the field?

Careful management of hydrocortisone in patients with undiagnosed adrenal insufficiency is crucial to prevent complications such as osmotic demyelination syndrome or refeeding syndrome. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

What question did this study set out to answer?

To highlight the risks associated with hydrocortisone administration in patients with undiagnosed adrenal insufficiency.

March 6, 2026Open Access

Pitfalls in the management of undiagnosed secondary adrenal insufficiency: a case report and review of the literature

Key Points

To highlight the risks associated with hydrocortisone administration in patients with undiagnosed adrenal insufficiency.
Case report on a patient with undiagnosed secondary adrenal insufficiency.
Review of existing literature on adrenal insufficiency management.
Analysis of complications related to hydrocortisone treatment.
Osmotic demyelination syndrome may occur due to changes in blood electrolytes.
Refeeding syndrome is a potential risk following hydrocortisone administration.

Abstract

Careful management is required while administering hydrocortisone in patients with undiagnosed adrenal insufficiency, as it may cause osmotic demyelination syndrome or refeeding syndrome due to sudden changes in blood electrolytes.

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