What question did this study set out to answer?

The study aims to compare the effectiveness of tenecteplase and alteplase as bridging therapies in acute ischemic stroke due to basilar artery occlusion.

March 6, 20260 citations

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Tenecteplase versus alteplase as bridging therapy before endovascular treatment in acute ischemic stroke due to Basilar artery occlusion: a systematic review and meta-analysis.

JFJoão Vítor Andrade FernandesUniversidade Federal da Paraíba JRJ. Mancha RamosUniversidade Federal da Paraíba GTGabriel Caruso Novaes TudellaUniversidade Federal de Santa Maria

Key Points

The study aims to compare the effectiveness of tenecteplase and alteplase as bridging therapies in acute ischemic stroke due to basilar artery occlusion.
Conducted a systematic review and meta-analysis
Compared outcomes of tenecteplase and alteplase as bridging therapies
Evaluated early and final reperfusion rates, hemorrhagic risk, and mortality
Tenecteplase improved early and final reperfusion rates
No increase in hemorrhagic risk or mortality with tenecteplase
Functional outcomes with tenecteplase were comparable to alteplase

Abstract

In BAO, tenecteplase as bridging therapy prior to EVT improves early and final reperfusion without increasing hemorrhagic risk or mortality, with functional outcomes comparable to alteplase, although the current evidence is limited.

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Cite This Study

Fernandes et al. (Tue,) studied this question.

synapsesocial.com/papers/69aa70e7531e4c4a9ff5b26d https://doi.org/https://doi.org/10.1080/01616412.2026.2640114

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