Magnetic-field based investigation detected characteristic electrophysiological alterations and alternans in saddleback and coved type Brugada syndrome and reproduced features like ST-segment elevation and T-wave inversion comparable to pseudo-ECG signals in a simulated right ventricular model.
Computational modeling demonstrates that magnetic-field based investigation can detect specific action potential disturbances and alternans in Brugada syndrome, offering a potential novel diagnostic perspective.
Brugada syndrome (BrS) is an inherited cardiac disorder associated with and increased risk of sudden cardiac death. The syndrome is associated with a complex current distribution and repolarization dispersion. The traditional methods for the diagnosis rely on standard electrocardiographic (ECG) assessment of the cardiac dynamics. Recent advancements in magnetocardiography suggest that the magnetic-field based investigation of cardiac electrophysiology could offer novel perspectives for the investigation of current abnormalities in BrS patients which go beyond the conventional ECG capabilities to capture intricate current distributions. In this work, we propose a framework for the magnetic analysis of action potential disturbances in Brugada syndrome. We exploit a 1D reduced-order cable geometry for analyzing the relation between the pathological electrical activity in saddleback and coved type BrS and the corresponding magnetic field. Also, we compute transmural pseudo-magnetocardiograms and demonstrate their capabilities of detecting both types of BrS. Overall, our result highlight the potential of magnetic-field oriented investigation of cardiac disturbances related to BrS.
Nicoletti et al. (Wed,) conducted a other in Patients with Brugada syndrome characterized by saddleback and coved type action potentials simulated in a 1D cable model resembling cardiac tissue. Magnetic-field based electrophysiological investigation vs. Standard electrocardiographic (ECG) assessment was evaluated on Detection and characterization of Brugada syndrome electrical abnormalities including alternans and typical ECG features via magnetic field (magnetocardiography) signatures. Magnetic-field based investigation detected characteristic electrophysiological alterations and alternans in saddleback and coved type Brugada syndrome and reproduced features like ST-segment elevation and T-wave inversion comparable to pseudo-ECG signals in a simulated right ventricular model.