Magnetic field based investigation of Brugada syndrome

Figures

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  Fig. 1. Action potential and magnetic field in healthy epicardium, mid myocardium and endocardium. a) Epicardial, endocardial and myocardial action potentials. We show healthy endocardial (in purple), epicardial (in black) and myocardial (in green) action potentials. In gray, a schematic representation of the APD90 of endocardial and epicardial action potentials. The three APs are represented for a fixed position along the cable during the stimulation with PCL=1000 ms. b) Conduction velocity. In the panel we report the conduction velocity computed for myocardial, epicardial and endocardial action potentials traveling on the cable as a function of the PCL. \documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$${\textbf {c) APD}}_{{\textbf {90}}}$$\end{document} restitution curves. The APD90 restitution curve are obtained calculating the APD90 for the last two beats of the series in fixed position along the cable and for each PCL. d) Magnetic field of epicardial myocardial and endocardial cells. The panel reports the…

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  Fig. 2. Action potential and magnetic field of Brugada syndrome. a) Healthy Epicardial, and Brugada syndrome action potentials. We show healthy epicardial (black), BrS saddleback type (blue) and BrS coved type (red) action potentials. In gray we show a schematic representation of the APD90 of normal epicardial action potentials. The three APs are represented for a fixed position along the cable during the stimulation with PCL=1000 ms. b) Conduction velocity. In the panel we report the conduction velocity computed for healthy and pathological action potentials traveling on the cable as a function of the PCL. c) APD60 restitution curves. The APD90 restitution curve in healthy and BrS coved and saddleback cases are obtained calculating the APD90 for the last two beats of the series in a fixed position along the cable and for each PCL. The insert shows a schematic representation of pathological coved action potentials during alternans regime. d) Magnetic field of healthy and pathological cases. The panel reports the time course of the magnetic field generated by normal epicardial, and BrS saddleback and coved action potentials. The representation shows the temporal behavior of the field for…

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  Fig. 3. Pseudo-ECG and MCG in health and BrS. a) Schematic representation of the simulation setup. The electrical activity is simulated on a 0.6 cm long cable resembling the composition of human right ventricle. b), c), d) Normal, BrS saddleback and BrS coved action potentials, pseudo-ECGs and pseudo-MCGs In the top rows we report endocardial, myocardial and epicardial action potentials at three different positions along the cable (top row). In the middle row we report the pseudo-ECG signals generated by the action potentials shown in the top row. In the bottom row we show the \documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$$B_y$$\end{document} component of the magnetic field representing the pseudo-magnetocardiogram. In the middle and bottom row the shaded gray curve represent the normal pseudo-ECG and MCG respectively