RAB3B regulates vesicle uptake and tight junction integrity in amniotic epithelial cells and is downregulated in premature rupture of membranes.

Key Points

• To investigate the role of RAB3B in vesicle uptake and tight junction integrity in amniotic epithelial cells and its connection to premature rupture of membranes.
• Analyzed RAB3B expression levels in amniotic epithelial cells under normal and PROM conditions.
• Assessed the integrity of tight junctions using specific molecular assays.
• Examined the role of RAB3B in extracellular vesicle (EV) transport.
• Utilized statistical analysis to evaluate the significance of findings.
• RAB3B expression was significantly lower in cases of PROM.
• Enhanced tight junctions were correlated with higher RAB3B levels.
• RAB3B facilitated material transport through extracellular vesicles, important for membrane repair.

Abstract