Copper-catalyzed tandem cyclization via (C–O) arylation and oxidative acylation for the construction of chromeno-fused isoxazole derivatives

Key Points

• The aim is to develop an efficient copper-catalyzed tandem reaction for synthesizing isoxazole derivatives.
• Used 3-phenylisoxazol-5(4 H)-one and ortho-halobenzaldehydes in a tandem reaction.
• Applied copper catalysis to facilitate C–O arylation and oxidative acylation.
• Successfully synthesized chromone-fused isoxazole derivatives.
• Identified these derivatives as valuable bioactive building blocks in medicinal chemistry.