Copper-catalyzed tandem cyclization via (C–O) arylation and oxidative acylation for the construction of chromeno-fused isoxazole derivatives

Rajnikant N. Ghoghari; Abha Patel; P. D. Patel; Kishor H. Chikhalia

doi:10.1039/d5nj04550a

January 1, 2026New Journal of Chemistry

Copper-catalyzed tandem cyclization via (C–O) arylation and oxidative acylation for the construction of chromeno-fused isoxazole derivatives

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Key Points

The aim is to develop an efficient copper-catalyzed tandem reaction for synthesizing isoxazole derivatives.
Used 3-phenylisoxazol-5(4 H)-one and ortho-halobenzaldehydes in a tandem reaction.
Applied copper catalysis to facilitate C–O arylation and oxidative acylation.
Successfully synthesized chromone-fused isoxazole derivatives.
Identified these derivatives as valuable bioactive building blocks in medicinal chemistry.

Implication

Tandem reaction produces bioactive chromone-fused isoxazole derivatives in medicinal chemistry, suggesting new drug leads.

Abstract

An efficient intermolecular copper-catalyzed tandem reaction of 3-phenylisoxazol-5(4 H )-one with ortho -halobenzaldehydes affords chromone-fused isoxazole derivatives, which are valuable bioactive building blocks in medicinal chemistry.

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Cite This Study

Ghoghari et al. (2026) studied this question.

synapsesocial.com/papers/69b4b9fb18185d8a398024ad https://doi.org/10.1039/d5nj04550a

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Copper-catalyzed tandem cyclization via (C–O) arylation and oxidative acylation for the construction of chromeno-fused isoxazole derivatives

Key Points

Implication

Abstract

Discussion

Cite This Study

Copper-catalyzed tandem cyclization via (C–O) arylation and oxidative acylation for the construction of chromeno-fused isoxazole derivatives

Key Points

Implication

Abstract

Discussion

Cite This Study

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