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January 1, 2026RSC AdvancesOpen Access

Copper-catalyzed one-pot synthesis of isoquinolines via oxidative α-amination under mild and sustainable conditions

Ali Akbari Danial Zand Hoseinshahi

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Key Points

This research aims to develop a copper-catalyzed method for the efficient synthesis of isoquinolines.
Utilized a multicomponent one-pot synthesis approach
Applied a modified Pomeranz–Fritsch-type cyclization
Conducted the synthesis under mild and sustainable conditions
Successfully synthesized isoquinolines in a single step
Achieved high yield and efficiency
Showed compatibility with various functional groups

Implication

Demonstrates efficient isoquinoline synthesis in a single step, suggesting a sustainable method for organic chemistry.

Abstract

Copper-catalyzed multicomponent one-pot synthesis of isoquinolines via a modified Pomeranz–Fritsch-type cyclization.

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Cite This Study

Akbari et al. (2026) studied this question.

synapsesocial.com/papers/69edacbd4a46254e215b47da https://doi.org/10.1039/d6ra01207h

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