What type of study is this?

This is a Meta-Analysis study (also classified as: Systematic Review).

What question did this study set out to answer?

The study evaluates the comparative efficacy and safety of potassium-competitive acid blockers versus proton pump inhibitors for erosive esophagitis.

March 15, 2026Open Access

Potassium-competitive Acid Blockers Versus Proton Pump Inhibitors for Erosive Esophagitis: A Systematic Review and Network Meta-analysis

Key Points

The study evaluates the comparative efficacy and safety of potassium-competitive acid blockers versus proton pump inhibitors for erosive esophagitis.
Conducted a systematic review and network meta-analysis of existing literature.
Compared efficacy and safety outcomes between P-CABs and PPIs in managing erosive esophagitis.
Focused on both initial and maintenance treatment.
P-CABs, particularly vonoprazan, demonstrated superior efficacy over PPIs.
Supported as a first-line treatment option for erosive esophagitis in high-risk populations.
Safety outcomes were found to be acceptable.

Abstract

P-CABs, especially vonoprazan, showed superior efficacy compared to PPIs in both the initial and maintenance treatment of EE. These findings support the use of P-CABs as a potent and reliable first-line option for EE management, particularly in high-risk populations, with acceptable safety outcomes.

Potassium-competitive Acid Blockers Versus Proton Pump Inhibitors for Erosive Esophagitis: A Systematic Review and Network Meta-analysis

Key Points

Abstract

Cite This Study

Also Consider

Also Consider