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March 13, 2026Journal of Neurogastroenterology and MotilityOpen Access

Potassium-competitive Acid Blockers Versus Proton Pump Inhibitors for Erosive Esophagitis: A Systematic Review and Network Meta-analysis

Jin Won Chang Da Hyun Jung Nak-Hoon Son Sohyeon Gwon Da Mi Jeong Cheal Wung Huh

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Key Points

The study evaluates the comparative efficacy and safety of potassium-competitive acid blockers versus proton pump inhibitors for erosive esophagitis.
Conducted a systematic review and network meta-analysis of existing literature.
Compared efficacy and safety outcomes between P-CABs and PPIs in managing erosive esophagitis.
Focused on both initial and maintenance treatment.
P-CABs, particularly vonoprazan, demonstrated superior efficacy over PPIs.
Supported as a first-line treatment option for erosive esophagitis in high-risk populations.
Safety outcomes were found to be acceptable.

Implication

Systematic review reveals P-CABs improve management and show greater efficacy than PPIs for erosive esophagitis.

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Cite This Study

Chang et al. (2026) studied this question.

synapsesocial.com/papers/69b5ff8d83145bc643d1c45d https://doi.org/10.5056/jnm25161

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