What question did this study set out to answer?

To evaluate how nutritional-inflammatory indices can enhance the diagnostic efficacy of FIB-4 in assessing advanced fibrosis and cirrhosis.

March 15, 2026Open Access

Nutritional-inflammatory indices optimize the diagnostic performance of FIB-4 for advanced fibrosis/cirrhosis in patients with benign liver disease

Key Points

To evaluate how nutritional-inflammatory indices can enhance the diagnostic efficacy of FIB-4 in assessing advanced fibrosis and cirrhosis.
Comparison of FIB-4 alone versus combination with nutritional indices
Analysis of sensitivity and specificity in diagnostic performance
Evaluation of sequential and parallel strategies for optimal results
FIB-4 alone is suitable for high sensitivity
Sequential strategy (FIB-4 + PAR and PNI) recommended for high specificity
Parallel strategy (FIB-4 + PAR or PNI) yields balanced performance

Abstract

In scenarios prioritizing high sensitivity, FIB-4 alone is suitable. For high specificity, a sequential strategy (FIB-4 + 'PAR and PNI') is recommended. For balanced performance, a parallel strategy (FIB-4 + 'PAR or PNI') provides optimal feasibility.

Nutritional-inflammatory indices optimize the diagnostic performance of FIB-4 for advanced fibrosis/cirrhosis in patients with benign liver disease

Key Points

Abstract

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