Sequential and parallel strategies enhance diagnostic performance of FIB-4 for advanced fibrosis in benign liver disease.
In scenarios prioritizing high sensitivity, FIB-4 alone is suitable. For high specificity, a sequential strategy (FIB-4 + 'PAR and PNI') is recommended. For balanced performance, a parallel strategy (FIB-4 + 'PAR or PNI') provides optimal feasibility.
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Zhou et al. (2026) studied this question.
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