Dysplasia in sessile serrated lesions: frequency, interobserver variability and added value of immunohistochemistry

Key Points

• The aim is to evaluate the reproducibility of dysplasia diagnosis in sessile serrated lesions among pathologists and the role of immunohistochemistry.
• Assessment of dysplasia frequencies in sessile serrated lesions by multiple pathologists
• Comparison of diagnostic outcomes between pathologists
• Evaluation of MLH1 immunohistochemistry in select cases
• Good reproducibility of SSLd diagnosis among pathologists
• Positive diagnostic trends noted over recent years
• MLH1 identified as the sole immunohistochemical marker of clinical utility for SSLd, but used selectively due to low prevalence

Abstract