This analysis examines interobserver variability in diagnosing dysplasia in sessile serrated lesions, suggesting enhanced diagnostic accuracy.
The diagnosis of SSLd appears to have good reproducibility among pathologists and positive diagnostic trends that are observed in recent years. MLH1 is the only IHC marker with robust clinical utility to identify SSLd that do not meet the morphologic criteria for overt dysplasia but should be used only in selected cases due to its low prevalence.
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Angerilli et al. (2026) studied this question.
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