Rational design and biological investigation of benzylidene-substituted pyrazolo3,4- b pyridine derivatives as novel PIM-1 kinase inhibitors with anticancer potential

Key Points

• The aim is to assess the potential of benzylidene-substituted pyrazolo[3,4-b]pyridine derivatives as anticancer agents through PIM-1 kinase inhibition.
• Synthesis of benzylidene-substituted pyrazolo[3,4-b]pyridine derivatives
• Biological evaluation of compounds for PIM-1 kinase inhibition
• Assessment of anticancer potential through relevant assays
• Identified compounds effectively inhibit PIM-1 kinase activity
• Demonstrated potential for developing novel anticancer therapies