What question did this study set out to answer?

The research aims to investigate the effects of Portulaca oleracea extract on wound healing in a rat model.

March 24, 2026

Portulaca oleracea L. extract improves wound healing and is associated with VEGF-related marker activation in a rat model of infected dorsal full-thickness skin wound

Key Points

The research aims to investigate the effects of Portulaca oleracea extract on wound healing in a rat model.
Used a rat model with fecal-contaminated dorsal skin wounds.
Applied topical Portulaca oleracea extract to the wounds.
Assessed histological outcomes and inflammation levels.
POL treatment improved histological outcomes.
Reduced inflammation was observed.
Increased VEGF-related markers were associated with the treatment.

Abstract

In a rat model of fecal-contaminated dorsal skin wound infection, topical POL treatment was associated with improved histological outcomes, reduced inflammation, and increased VEGF-related markers. These findings suggest a potential role for POL in promoting infected wound healing, although the VEGF involvement is based on associative expression data and requires further mechanistic validation.

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