Importantly, KRG restored ACSM3 expression and attenuated type I collagen deposition, consistent with in vivo results. Conclusion:In conclusion, KRG alleviates renal fibrosis in agingrelated CKD by restoring ACSM3 and modulating epigenetic and profibrotic signaling.The recovery of ACSM3, accompanied by reduced H3K27ac and TGF-/Smad3 activation, represents a key molecular axis through which KRG exerts anti-fibrotic effects.These findings highlight ACSM3 as a novel molecular target of KRG and support its therapeutic potential for aging-related CKD.
Shindoh et al. (Wed,) studied this question.