⌘+K

Pulse Explore Clubs Researchers Journals

Home Clubs Explore

March 25, 2026Kidney International ReportsOpen Access

Wcn26-6073 Tw-37, a Blocker of Kim-1-Dependent Endocytosis, Suppresses Cellular Senescence and Associated Phenomena

Ryota Shindoh Makiko Mori Yuki Nakao Yuta Sekiguchi Shintaro Mandai Hiroaki Kikuchi Fumiaki Ando Koichiro Susa Takayasu Mori Eisei Sohara Shinichi Uchida Yutaro Mori

View Full Paper

Ask AI

Bookmark

Share

Key Points

The central aim is to investigate how TW-37 impacts cellular senescence and renal fibrosis in aging-related chronic kidney disease (CKD).
Assessment of KIM-1 blockade using TW-37 in cellular models
Analysis of ACSM3 expression and collagen deposition
Investigation of epigenetic signaling pathways involved in fibrosis
TW-37 reduced markers of cellular senescence
Increased ACSM3 expression was observed
Type I collagen deposition was significantly decreased

Implication

Demonstrates that TW-37 alleviates renal fibrosis in aging-related CKD, suggesting therapeutic potential.

Discussion

No takes yet. Share an insight, caveat, or question.

Cite This Study

Shindoh et al. (2026) studied this question.

synapsesocial.com/papers/69c76fff8bbfbc51511e056b https://doi.org/10.1016/j.ekir.2026.105391

View Full Paper

Ask AI

Bookmark

Share

Keep reading

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1WCN26-6079 Pre-injury Loss of Tcf21 in Interstitial Cells Attenuates Renal Interstitial FibrosisOriginal Research · 2026
2WCN26-6006 NEPRILYSIN KNOCKOUT MITIGATES TUBULOINTERSTITIAL INJURY AND FIBROSIS IN A RAT MODEL OF RENAL CONGESTIONOriginal Research · 2026
3Targeted inhibition of RGS19 alleviates renal fibrosis by restoring autophagy and modulating immune cell infiltrationOriginal Research · 2026 · 1 citations
4CG200745, a Novel HDAC Inhibitor, Attenuates Kidney Fibrosis in a Murine Model of Alport Syndromepreclinical · 2020 · 15 citations
5WCN24-1328 THE ADMINISTRATION OF EXTRACELLULAR VESICLES DERIVED FROM MESENCHYMAL STEM CELLS PROMOTED SIGNIFICANT RENOPROTECTION IN A SEVERE EXPERIMENTAL CKD MODEL2024