Impact of early vs. late initiation of continuous renal replacement therapy on composite outcomes including acute kidney disease and mortality: a multicenter propensity-matched cohort study (LINKA cohort)

Key Points

• To assess the impact of the timing of continuous renal replacement therapy (CRRT) initiation on kidney-related outcomes and mortality.
• Multicenter cohort study design
• Propensity matching to balance baseline characteristics
• Comparison of early vs late CRRT initiation
• Analysis of composite outcomes including acute kidney disease and mortality
• Early CRRT initiation improved kidney-related outcomes
• More pronounced benefits observed in patients with lower baseline renal function
• Supports individualized CRRT timing based on patient-specific factors