Impact of early vs. late initiation of continuous renal replacement therapy on composite outcomes including acute kidney disease and mortality: a multicenter propensity-matched cohort study (LINKA cohort)

Sangil Min; Sung Gyun Kim; Jung Nam An; Sejoong Kim; LINKA* investigators

doi:10.23876/j.krcp.25.421

March 25, 2026Kidney Research and Clinical PracticeOpen Access

Impact of early vs. late initiation of continuous renal replacement therapy on composite outcomes including acute kidney disease and mortality: a multicenter propensity-matched cohort study (LINKA cohort)

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Key Points

To assess the impact of the timing of continuous renal replacement therapy (CRRT) initiation on kidney-related outcomes and mortality.
Multicenter cohort study design
Propensity matching to balance baseline characteristics
Comparison of early vs late CRRT initiation
Analysis of composite outcomes including acute kidney disease and mortality
Early CRRT initiation improved kidney-related outcomes
More pronounced benefits observed in patients with lower baseline renal function
Supports individualized CRRT timing based on patient-specific factors

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Implication

A multicenter cohort study shows improved kidney outcomes in patients with early CRRT, suggesting individualized timing based on function.

Abstract

Early CRRT initiation was associated with improved kidney-related outcomes, particularly in patients with lower baseline renal function. These findings support a more individualized approach to CRRT timing based on baseline kidney function.

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Cite This Study

Min et al. (2026) studied this question.

synapsesocial.com/papers/69c770418bbfbc51511e085f https://doi.org/10.23876/j.krcp.25.421

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Impact of early vs. late initiation of continuous renal replacement therapy on composite outcomes including acute kidney disease and mortality: a multicenter propensity-matched cohort study (LINKA cohort)

Key Points

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

Impact of early vs. late initiation of continuous renal replacement therapy on composite outcomes including acute kidney disease and mortality: a multicenter propensity-matched cohort study (LINKA cohort)

Key Points

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

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