Ganglion Cell Layer Compared With Inner Plexiform Layer Atrophy After Optic Neuritis Associated With NMOSD, MOGAD, and MS

Key Points

• The aim is to examine the differences in atrophy between the ganglion cell layer and inner plexiform layer after optic neuritis associated with various neuroinflammatory conditions.
• Compared measurements of ganglion cell layer (GCL) and inner plexiform layer (IPL) thickness after optic neuritis (ON).
• Analyzed data from patients with multiple sclerosis (MS), MOG antibody-associated disease (MOGAD), and AQP4+ NMOSD.
• Calculated the GCL/GCIPL ratio to assess the extent of atrophy.
• More severe thinning of the ganglion cell layer and inner plexiform layer was observed post-ON.
• A lower GCL/GCIPL ratio correlated with increased GCL thinning compared to IPL.
• The atrophy patterns were consistent across all neuroinflammatory conditions studied.