Ganglion Cell Layer Compared With Inner Plexiform Layer Atrophy After Optic Neuritis Associated With NMOSD, MOGAD, and MS

Angeliki Filippatou; Georgios Gakis; Anna Bacchetti; A. Kim; Yana Said; B. A. O. McCormack; Ting-Yi Lin; Adam M. Didouchevski; Nicole Pellegrini; Kathryn C. Fitzgerald; Peter A. Calabresi; Shiv Saidha; Elias S. Sotirchos

doi:10.1212/nxi.0000000000200567

March 25, 2026Neurology Neuroimmunology & NeuroinflammationOpen Access

Ganglion Cell Layer Compared With Inner Plexiform Layer Atrophy After Optic Neuritis Associated With NMOSD, MOGAD, and MS

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Key Points

The aim is to examine the differences in atrophy between the ganglion cell layer and inner plexiform layer after optic neuritis associated with various neuroinflammatory conditions.
Compared measurements of ganglion cell layer (GCL) and inner plexiform layer (IPL) thickness after optic neuritis (ON).
Analyzed data from patients with multiple sclerosis (MS), MOG antibody-associated disease (MOGAD), and AQP4+ NMOSD.
Calculated the GCL/GCIPL ratio to assess the extent of atrophy.
More severe thinning of the ganglion cell layer and inner plexiform layer was observed post-ON.
A lower GCL/GCIPL ratio correlated with increased GCL thinning compared to IPL.
The atrophy patterns were consistent across all neuroinflammatory conditions studied.

Implication

Compares atrophy in eye layers after optic neuritis across neuroinflammatory conditions, suggesting key relationships.

Abstract

More severe GCIPL thinning after ON was associated with a lower GCL/GCIPL ratio, supporting that more GCL than IPL thinning occurs after ON. The pattern was similar across neuroinflammatory conditions including MS, MOGAD, and AQP4+NMOSD. Our findings may help shed light into dynamics of inner retinal layer atrophy after ON.

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Cite This Study

Filippatou et al. (2026) studied this question.

synapsesocial.com/papers/69c770c08bbfbc51511e0c51 https://doi.org/10.1212/nxi.0000000000200567

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Ganglion Cell Layer Compared With Inner Plexiform Layer Atrophy After Optic Neuritis Associated With NMOSD, MOGAD, and MS

Key Points

Implication

Abstract

Discussion

Cite This Study

Ganglion Cell Layer Compared With Inner Plexiform Layer Atrophy After Optic Neuritis Associated With NMOSD, MOGAD, and MS

Key Points

Implication

Abstract

Discussion

Cite This Study

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