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September 4, 2024Journal of Neuro-Ophthalmology

Recurrence-Independent Progressive Inner-Retinal Thinning After Optic Neuritis: A Longitudinal Study

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Authors

YMYeji MoonYGYujin GimKPKyung-Ah Park

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Overview

Multicenter retrospective observational study demonstrates progressive inner retinal thinning in demyelinating optic neuritis, highlighting ongoing subclinical damage independent of relapses.

Key Points

  • Demyelinating optic neuritis leads to ongoing inner retinal thinning across multiple subtypes, revealing subclinical neuroaxonal loss despite the absence of clinical disease relapses.
  • Multicenter retrospective observational study of 77 patients revealed peripapillary retinal nerve fiber layer loss of 0.66 μm/year in AQP4 disease and 0.53 μm/year in multiple sclerosis.
  • Highlights the need for long-term optical coherence tomography surveillance and neuroprotective strategies, as older age accelerates macular ganglion cell-inner plexiform layer thinning.

Cite This Study

Moon et al. (2024) studied this question.

synapsesocial.com/papers/68e5968ab6db6435875310fchttps://doi.org/10.1097/wno.0000000000002244
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Comparison of macular changes according to the etiology of optic neuritis: a cross-sectional study2024
  2. 2Fifteen-Year Longitudinal Changes in Peripapillary Retinal Nerve Fiber Layer Thickness in Multiple Sclerosis2026
  3. 3Optic neuritis in various demyelinating diseases2024
  4. 4Retinal Nerve Fiber Layer and Optic Nerve Head Measurements in Eyes without Optic Neuritis: A Spectral-Domain OCT Comparison Across MOGAD, MS, and Controls2026
  5. 5Investigating the impact of age on neurodegeneration after optic neuritis in multiple sclerosis using optical coherence tomography2025