What question did this study set out to answer?

To evaluate differences in pRNFL thickness and ONH parameters among MOGAD, MS, and healthy controls.

July 2, 2026Neuro-Ophthalmology

Retinal Nerve Fiber Layer and Optic Nerve Head Measurements in Eyes without Optic Neuritis: A Spectral-Domain OCT Comparison Across MOGAD, MS, and Controls

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Authors

KDKadriye DemirSakarya University NANilgün Özkan AksoySakarya University DKDilcan KotanSakarya University

Discussion

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Implication

Retrospective observational study compares retinal nerve fiber layer and optic nerve head in MOGAD, MS, and healthy controls, indicating differences in neurodegeneration.

Key Points

To evaluate differences in pRNFL thickness and ONH parameters among MOGAD, MS, and healthy controls.
Retrospective observational study with 63 participants (21 MOGAD, 21 MS, 21 controls).
Used spectral-domain optical coherence tomography for measuring pRNFL thickness and ONH parameters.
Included only NON eyes without evidence of optic neuritis.
Average pRNFL thickness was significantly lower in MS compared to MOGAD and controls (p = 0.001).
Optic disc area was larger in MOGAD patients (p = 0.03).
Cup volume was greater in healthy controls (p = 0.002), while rim area and cup-to-disc ratios showed no significant differences.

Cite This Study

Demir et al. (2026) studied this question.

synapsesocial.com/papers/6a45ff6f9ed134303130fd32 https://doi.org/10.1080/01658107.2026.2693205

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Implication

Retrospective observational study compares retinal nerve fiber layer and optic nerve head in MOGAD, MS, and healthy controls, indicating differences in neurodegeneration.

Retinal Nerve Fiber Layer and Optic Nerve Head Measurements in Eyes without Optic Neuritis: A Spectral-Domain OCT Comparison Across MOGAD, MS, and Controls

Discussion

Member takes

Implication

Key Points

Cite This Study

Retinal Nerve Fiber Layer and Optic Nerve Head Measurements in Eyes without Optic Neuritis: A Spectral-Domain OCT Comparison Across MOGAD, MS, and Controls

Discussion

Member takes

Implication

Key Points

Cite This Study

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