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October 23, 2025Multiple Sclerosis JournalOpen Access

Investigating the impact of age on neurodegeneration after optic neuritis in multiple sclerosis using optical coherence tomography

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Authors

HRHenriette ReinsbergFOFrederike Cosima OertelDCDaniel Casillas

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Overview

Observational analysis reveals neurodegeneration in older individuals after optic neuritis in multiple sclerosis, indicating potential risk for long-term disability.

Key Points

  • Increased neurodegeneration is associated with age after optic neuritis in multiple sclerosis patients, highlighting the vulnerability of older individuals.
  • Older patients showed significant declines in retinal nerve fibre layer and ganglion cell thickness, reflected by confidence intervals indicating statistical validity.
  • Assessment of retinal metrics was performed using advanced imaging techniques, focusing on peripapillary retinal nerve fibre layer and macular ganglion cell inner plexiform layer.
  • Longitudinal studies are needed to further understand the implications of age on chronic neurodegeneration and associated risks.

Cite This Study

Reinsberg et al. (2025) studied this question.

synapsesocial.com/papers/68fa1210f9f8b44535bfcd16https://doi.org/10.1177/13524585251374507
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Recurrence-Independent Progressive Inner-Retinal Thinning After Optic Neuritis: A Longitudinal Study2024 · 1 citations
  2. 2Fifteen-Year Longitudinal Changes in Peripapillary Retinal Nerve Fiber Layer Thickness in Multiple Sclerosis2026
  3. 3Study of neurodegeneration in multiple sclerosis using optical coherence tomography of the retina and magnetic resonance morphometry of the brain2025
  4. 4Retinal Nerve Fiber Layer and Optic Nerve Head Measurements in Eyes without Optic Neuritis: A Spectral-Domain OCT Comparison Across MOGAD, MS, and Controls2026
  5. 5Optical coherence tomography: a tool for predicting subclinical neurodegeneration in RRMS2026