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September 10, 2025S S Korsakov Journal of Neurology and Psychiatry

Study of neurodegeneration in multiple sclerosis using optical coherence tomography of the retina and magnetic resonance morphometry of the brain

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Authors

TST. V. ShchukinaГБГ. Н. БисагаVMV. A. Malko

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Overview

Observational analysis finds retinal changes correlate with brain volume in multiple sclerosis patients, suggesting new diagnostic routes.

Key Points

  • A direct correlation exists between retinal thickness and brain volume in multiple sclerosis patients, indicating neurodegeneration.
  • The transverse size of the ganglion cell layer most strongly correlates with brain parameters, especially gray and white matter volumes.
  • Magnetic resonance morphometry and optical coherence tomography were utilized to assess brain and retinal structure in patients.
  • These findings support using retinal measures as potential indicators of central nervous system neurodegeneration.

Cite This Study

Shchukina et al. (2025) studied this question.

synapsesocial.com/papers/68c1bd3b54b1d3bfb60ee5eahttps://doi.org/10.17116/jnevro202512507266
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Exploring the relationship between retinal damage and cognition in multiple sclerosis: a cross-sectional OCT-MRI study2026
  2. 2Optical Coherence Tomography as a Proxy for Accelerated Brain Aging and Multimodal Neurodegeneration in Multiple Sclerosis2026
  3. 3Retinal macrophage-like cell activation and ganglion cell layer thinning are associated with disability and MRI lesion burden in multiple sclerosis2026
  4. 4Evolution of retinal degeneration and prediction of disease activity in relapsing and progressive multiple sclerosis2024 · 20 citations
  5. 5Structural and Functional Assessment of the Macular Inner Retinal Layers in Multiple Sclerosis Eyes Without History of Optic Neuropathy2025 · 1 citations