What question did this study set out to answer?

This research aims to explore the relationship between retinal macrophage-like cell characteristics, ganglion cell thickness, clinical disability, and MRI lesions in multiple sclerosis.

May 24, 2026PLoS ONEOpen Access

Retinal macrophage-like cell activation and ganglion cell layer thinning are associated with disability and MRI lesion burden in multiple sclerosis

View Full Paper

Ask AI

Bookmark

Authors

FPFrancesco PichiCleveland Clinic YJYanny Perez JimenezEmirates Foundation MBMatteo BellettiAzienda USL di Bologna

Discussion

Member takes

Implication

Cross-sectional observational study finds links between retinal changes and disability in multiple sclerosis, suggesting imaging could help track disease progression.

Key Points

This research aims to explore the relationship between retinal macrophage-like cell characteristics, ganglion cell thickness, clinical disability, and MRI lesions in multiple sclerosis.
Cross-sectional observational study with patients having multiple sclerosis and age-matched controls.
Retinal imaging was performed using spectral-domain and swept-source optical coherence tomography.
Clinical disability assessed via the Expanded Disability Status Scale, 9-Hole Peg Test, and 25-Foot Walk; MRI lesion counts obtained from T1 and T2 sequences.
Increased retinal macrophage-like cell count was linked to Expanded Disability Status Scale scores of five or higher.
Moderate positive association found between macrophage size and T2 lesion burden; weak with T1 lesions.
Ganglion cell layer thickness was significantly reduced in patients compared to controls.

Cite This Study

Pichi et al. (2026) studied this question.

synapsesocial.com/papers/6a12962948a0ea1665672bf8 https://doi.org/10.1371/journal.pone.0349679

View Full Paper

Ask AI

Bookmark

May 24, 2026PLoS ONEOpen Access

Retinal macrophage-like cell activation and ganglion cell layer thinning are associated with disability and MRI lesion burden in multiple sclerosis

View Full Paper

Ask AI

Bookmark

Authors

FPFrancesco PichiCleveland Clinic YJYanny Perez JimenezEmirates Foundation MBMatteo BellettiAzienda USL di Bologna

Discussion

Member takes

Implication

Cross-sectional observational study finds links between retinal changes and disability in multiple sclerosis, suggesting imaging could help track disease progression.

Key Points

This research aims to explore the relationship between retinal macrophage-like cell characteristics, ganglion cell thickness, clinical disability, and MRI lesions in multiple sclerosis.
Cross-sectional observational study with patients having multiple sclerosis and age-matched controls.
Retinal imaging was performed using spectral-domain and swept-source optical coherence tomography.
Clinical disability assessed via the Expanded Disability Status Scale, 9-Hole Peg Test, and 25-Foot Walk; MRI lesion counts obtained from T1 and T2 sequences.
Increased retinal macrophage-like cell count was linked to Expanded Disability Status Scale scores of five or higher.
Moderate positive association found between macrophage size and T2 lesion burden; weak with T1 lesions.
Ganglion cell layer thickness was significantly reduced in patients compared to controls.

Cite This Study

Pichi et al. (2026) studied this question.

synapsesocial.com/papers/6a12962948a0ea1665672bf8 https://doi.org/10.1371/journal.pone.0349679

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

View Full Paper

Ask AI

Bookmark