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August 21, 2025Journal of Clinical MedicineOpen Access

Structural and Functional Assessment of the Macular Inner Retinal Layers in Multiple Sclerosis Eyes Without History of Optic Neuropathy

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Authors

LBLucilla BarbanoFondazione G.B. BiettiLZLucia ZiccardiUniversity of MoliseCDCarmen Dell’AquilaFondazione G.B. Bietti

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Overview

Finds reduced macular ganglion cell layer thickness and retinal ganglion cell function in multiple sclerosis, suggesting potential underlying involvement in the inner retina.

Key Points

  • Reduced macular ganglion cell layer thickness and retinal function suggest retinal impairment in multiple sclerosis.
  • Significant reductions were noted in macular thickness and response amplitude density in 24 MSnoON patients versus controls.
  • Assessment using optical coherence tomography and multifocal photopic negative response was conducted to evaluate inner retinal layers.
  • Implications highlight the need for further investigation into primary retinal changes in multiple sclerosis patients.

Cite This Study

Barbano et al. (2025) studied this question.

synapsesocial.com/papers/68af55c6ad7bf08b1eadbc84https://doi.org/10.3390/jcm14165919
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Topographical Correlation between Structural and Functional Impairment of the Macular Inner Retinal Layers in Multiple Sclerosis Eyes with a History of Optic Neuropathy2023 · 4 citations
  2. 2The APOSTEL recommendations for reporting quantitative optical coherence tomography studies2016 · 420 citations
  3. 3Functional Assessment of Outer and Middle Macular Layers in Multiple Sclerosis2020 · 6 citations
  4. 4Structure–Function Relationship of Retinal Ganglion Cells in Multiple Sclerosis2021 · 13 citations
  5. 5Focal Thickness Reduction of the Ganglion Cell-Inner Plexiform Layer Best Discriminates Prior Optic Neuritis in Patients With Multiple Sclerosis2019 · 21 citations