Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
December 4, 2025Brain CommunicationsOpen Access

In vivo characterization of a retinal cellular biomarker of inflammation in multiple sclerosis

View Full Paper
Ask AI
Bookmark
Share

Authors

NNNathaniel NorbergKGKate Grieve

Discussion

Loading...

Member takes

Overview

Prospective cohort study shows neural inflammation changes post-optic neuritis in MS, indicating adaptive optics imaging's potential utility.

Key Points

  • Retinal imaging captured immune responses in MS patients, suggesting a relationship to neurodegeneration.
  • Cellular dynamics were observed using adaptive optics scanning laser ophthalmoscopy, revealing inflammation patterns.
  • Optic neuritis patients exhibited high-density cellular infiltrates, with immune cells detected in the retinal ganglion cell layer.
  • Immigration of lymphocyte-like cells near blood vessels suggests complex interactions during neuroinflammation.

Cite This Study

Norberg et al. (2025) studied this question.

synapsesocial.com/papers/6930dc78ea1aef094cca22a7https://doi.org/10.1093/braincomms/fcaf471
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Non-invasive in vivo imaging assessment of retinal microglia-like cells in diabetic retinopathy by adaptive optics optical coherence tomography2026
  2. 2Retinal macrophage-like cell activation and ganglion cell layer thinning are associated with disability and MRI lesion burden in multiple sclerosis2026
  3. 3Longitudinal Optical Coherence Tomography Imaging Reveals Hyperreflective Foci Characteristics in Relapsing–Remitting Multiple Sclerosis Patients2024
  4. 4Recurrence-Independent Progressive Inner-Retinal Thinning After Optic Neuritis: A Longitudinal Study2024 · 1 citations
  5. 5Optic Coherence Tomography Angiography in Multiple Sclerosis: A Tool for Evaluation of Neuroinflammation2024