Degradation Kinetics of Apomorphine Hydrochloride in Buffered Formulations and the Effect of Antioxidants

Key Points

• The research aims to explore how antioxidants influence the degradation kinetics of apomorphine hydrochloride in buffered solutions.
• Examined degradation kinetics of apomorphine hydrochloride in various buffered formulations
• Added different concentrations of antioxidants to the formulations
• Measured stability at varying pH levels
• Determined that apomorphine maintains greater stability at pH 2.4-2.6
• Identified 1% ascorbic acid (AA) as effective for maximizing drug stability
• Noted optimal formulations for clinical tolerability
• Showed a significant relationship between pH and degradation rate