PulseExploreJournal ClubDebatesTrendingResearchersJournals
Instagram
HomeExploreJournal ClubTrending
Synapse
⌘+K
Synapse
March 28, 2026Drug Development and Industrial Pharmacy0 citations

Degradation Kinetics of Apomorphine Hydrochloride in Buffered Formulations and the Effect of Antioxidants

View Full Paper
AAAbeer M. Al-GhananeemSBSarah BaltzleyAMAzzam Malkawi

Key Points

  • The research aims to explore how antioxidants influence the degradation kinetics of apomorphine hydrochloride in buffered solutions.
  • Examined degradation kinetics of apomorphine hydrochloride in various buffered formulations
  • Added different concentrations of antioxidants to the formulations
  • Measured stability at varying pH levels
  • Determined that apomorphine maintains greater stability at pH 2.4-2.6
  • Identified 1% ascorbic acid (AA) as effective for maximizing drug stability
  • Noted optimal formulations for clinical tolerability
  • Showed a significant relationship between pH and degradation rate

Abstract

The APO aqueous formulation at pH 2.4-2.6 with 1% AA is recommended to maximize stability and clinical tolerability.

Ask AI
Helpful
Bookmark
Share
View Full Paper

Cite This Study

Al-Ghananeem et al. (2026) studied this question.

synapsesocial.com/papers/69c771838bbfbc51511e169fhttps://doi.org/10.1080/03639045.2026.2652043
Ask AI
Helpful
Bookmark
Share
View Full Paper