What question did this study set out to answer?

This research aims to examine how anxiety and worry symptoms relate to cognitive performance among midlife women, particularly those with the APOE4 genotype.

March 30, 2026

Associations of anxiety and worry symptoms with cognitive performance among midlife women: importance of APOE4 genotype status

Key Points

This research aims to examine how anxiety and worry symptoms relate to cognitive performance among midlife women, particularly those with the APOE4 genotype.
Analyzed cognitive performance metrics among midlife women
Compared symptoms of anxiety and worry in APOE4 carriers versus non-carriers
Evaluated the implications of cognitive outcomes based on genotype status
APOE4 carriers showed a significant association between anxiety symptoms and reduced cognitive performance
Worry symptoms adversely impacted cognitive functioning in midlife women overall
Treatment of anxiety symptoms may improve cognitive outcomes for women with the APOE4 genotype

Abstract

Findings underscore the importance of anxiety and worry for women's cognitive performance at midlife among APOE4 carriers. They suggest the potential value of treating anxiety symptoms in APOE4 carriers to support women's cognition at midlife and beyond.

Associations of anxiety and worry symptoms with cognitive performance among midlife women: importance of APOE4 genotype status

Key Points

Abstract

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