Associations of anxiety and worry symptoms with cognitive performance among midlife women: importance of APOE4 genotype status

Key Points

• This research aims to examine how anxiety and worry symptoms relate to cognitive performance among midlife women, particularly those with the APOE4 genotype.
• Analyzed cognitive performance metrics among midlife women
• Compared symptoms of anxiety and worry in APOE4 carriers versus non-carriers
• Evaluated the implications of cognitive outcomes based on genotype status
• APOE4 carriers showed a significant association between anxiety symptoms and reduced cognitive performance
• Worry symptoms adversely impacted cognitive functioning in midlife women overall
• Treatment of anxiety symptoms may improve cognitive outcomes for women with the APOE4 genotype